Clinical Evidence for Electrolyzed Water Hemodialysis and Raising Awareness

「At the 71st Annual Meeting of the Japanese Society for Dialysis Therapy held in June this year, 8 presentations related to electrolyzed-water dialysis were given. We are continuing to communicate information actively, and recognition is steadily increasing. Inquiries and specific business discussions arising from the conference are also progressing.」

「At the 70th Annual Scientific Meeting and General Assembly of the Japanese Society for Dialysis Therapy held last June, 4 presentations related to Electrolyzed Water Hemodialysis were given. More than 300 healthcare professionals involved in dialysis treatment, including doctors, clinical engineers and nurses, attended the luncheon seminar “New Possibilities for Electrolyzed Water Hemodialysis,” demonstrating steadily rising interest. At the 2nd Electrolyzed Water Hemodialysis Research Society Scientific Meeting in July, active discussion took place based on presentations on Electrolyzed Water Hemodialysis. In addition, seminars on Electrolyzed Water Hemodialysis were held at the 5th Annual Scientific Meeting and General Assembly of the Japanese Society for Renal Failure Complications in February this year and the 52nd Annual Scientific Meeting and General Assembly of the Japanese Society for Blood Purification Technology in April, receiving considerable interest.」

「We will continue working to strengthen the evidence base and improve dialysis equipment, with the aim of expanding adoption as a next-generation global standard therapy.」

「Interest in the annual Annual Scientific Meeting and General Assembly of the Japanese Society for Dialysis Therapy has been increasing, and business discussions are progressing with facilities that became interested in Electrolyzed Water Hemodialysis through the meeting. We will continue working to expand adoption through exhibitions at dialysis-related conferences and seminars.」

「At the 69th Annual Scientific Meeting and General Assembly of the Japanese Society for Dialysis Therapy held last June, 9 presentations related to Electrolyzed Water Hemodialysis were given. In addition, more than 300 people involved in dialysis treatment, including doctors and clinical engineers, attended the luncheon seminar “Electrolyzed Water Hemodialysis: Breakthrough,” demonstrating steadily rising awareness. At the 1st Electrolyzed Water Hemodialysis Research Society Scientific Meeting held in July, 15 presentations were given on the benefits for patients, dialysis staff and dialysis-facility management.」

「Awareness and interest in Electrolyzed Water Hemodialysis are steadily increasing, and we will continue to expand its adoption.」

「Electrolyzed Water Hemodialysis is a revolutionary technology developed in Japan that can make a major contribution to dialysis patients’ well-being. We will continue strengthening the evidence and improving the dialysis equipment, with the aim of expanding adoption as the next global-standard therapy.」

「At the luncheon seminar “Electrolyzed Water Hemodialysis: New Discovery,” held at the 68th Annual Scientific Meeting and General Assembly of the Japanese Society for Dialysis Therapy in June this year at the Kobe International Conference Center, more than 360 people involved in dialysis treatment, including doctors and clinical engineers, attended. This demonstrated growing awareness of Electrolyzed Water Hemodialysis and an increase in facilities willing to adopt it. We are now in new business discussions with approximately 60 facilities that responded positively to adoption in the conference survey. Evaluations of Electrolyzed Water Hemodialysis have risen further as a result of various papers and presentations at academic conferences.」

「In Electrolyzed Water Hemodialysis, we published a joint paper last July in Renal Replacement Therapy with St. Luke’s International Hospital, Nikkō Memorial Hospital and others on reducing severe fatigue in dialysis patients through Electrolyzed Water Hemodialysis. Joint research conducted mainly with Tohoku University and collaborating institutions including St. Luke’s International Hospital has continued to build evidence of the expected benefits of Electrolyzed Water Hemodialysis, including reduced fatigue and crude mortality among dialysis patients, as well as its safety.」

「Electrolyzed Water Hemodialysis is attracting attention as a novel treatment developed in Japan that can contribute to patients’ well-being by reducing the fatigue suffered by many dialysis patients, thereby improving their quality of life and helping them return home and to society. We will also conduct publicity activities using mass media such as newspapers to raise awareness among healthcare professionals and patients. There are approximately 4,500 dialysis facilities in Japan, and we will continue to focus on expanding adoption with the aim of making it a global standard.」

「In the Electrolyzed Water Hemodialysis business (*1), we published a joint paper in Renal Replacement Therapy in July this year with St. Luke’s International Hospital, Nikkō Memorial Hospital and others on reducing severe fatigue in dialysis patients through Electrolyzed Water Hemodialysis. Reducing the fatigue that causes the greatest suffering for many dialysis patients can help them return home and to society, and achieving well-being through improved quality of life has considerable social and economic significance. We will continue working to strengthen the evidence further and expand the adoption of Electrolyzed Water Hemodialysis.」

「The “Survey of Electrolyzed Water Hemodialysis in Clinical Practice” reported that the crude mortality rate among 1,392 Electrolyzed Water Hemodialysis patients was 4.2%, less than half the 9.9% rate for dialysis patients in Japan, based on 2020 JSDT statistical data. The findings indicated the possibility of extending dialysis survival.」

「At the 66th Annual Scientific Meeting and General Assembly of the Japanese Society for Dialysis Therapy held last June, reports were presented showing that, after Electrolyzed Water Hemodialysis treatment, dosages of antihypertensive drugs fell by 21.6% and dosages of anemia treatments fell by 17.3%. An observational finding was also presented showing that the crude mortality rate among Electrolyzed Water Hemodialysis patients was 3.7%, 6.4 percentage points below the 10.1% crude mortality rate for dialysis patients in Japan.」

「Three of these facilities have received JCI (Joint Commission International) accreditation, which is recognized as having the world’s most rigorous standards for healthcare quality and patient safety. Electrolyzed Water Hemodialysis is also gaining recognition in medical settings where the highest level of safety is required.」

「At the 66th Annual Scientific Meeting and General Assembly of the Japanese Society for Dialysis Therapy held in June this year, a survey of 950 patients at 10 facilities receiving Electrolyzed Water Hemodialysis in 2020 showed that the 1-year crude mortality rate was 3.7%, lower than the national average of 10.1%. In July this year, a joint paper by St. Luke’s International Hospital, Tohoku University Hospital and Yoko-dai Central Clinic of Hou shinkai Medical Corporation was published in Renal Replacement Therapy, the English-language journal of the Japanese Society for Dialysis Therapy.」

「In the fiscal year ended March 2021, we focused on web marketing. Although this was our first such initiative, holding a web seminar at the Japanese Society for Dialysis Therapy and providing it on demand led to new business discussions with 35 facilities. Video distribution on m3.com also enabled us to reach 174 doctors, giving us a sense of traction.」

「At the Japanese Society for Dialysis Therapy meeting held in November, we conducted a web seminar and on-demand distribution, generating approximately 1,600 views in total. This demonstrated growing awareness and interest among dialysis healthcare professionals.」

「Electrolyzed Water Hemodialysis is expected to improve patients’ quality of life and prognosis while also contributing to hospital profitability, and we have begun initiatives to demonstrate these effects.」

「In the Electrolyzed Water Hemodialysis business, awareness and expectations have steadily increased since the publication in the British scientific journal Scientific Reports in 2018 of a paper reporting that Electrolyzed Water Hemodialysis reduced deaths and the diseases causing them by 41%. Seminars for researchers and dialysis healthcare professionals have also received an extremely positive response, with many inquiries and an increasing number of prospective adopting facilities.」

「At the 64th Annual Scientific Meeting and General Assembly of the Japanese Society for Dialysis Therapy, held at Pacifico Yokohama in June this year, 3 presentations related to Electrolyzed Water Hemodialysis were given. In addition, 370 doctors, clinical engineers, nurses and others attended the luncheon seminar, which was so well attended that some participants had to stand.」

「Following the publication in January this year of our paper in Scientific Reports, a British scientific journal published by the Nature Publishing Group, we have received considerable interest because Electrolyzed Water Hemodialysis is expected to improve dialysis patients’ quality of life while also contributing to hospital management. At the 63rd Annual Scientific Meeting and General Assembly of the Japanese Society for Dialysis Therapy, held in Kobe in June, we received more than 500 questionnaire responses, approximately three times as many as last year, while all 250 seats at the luncheon seminar were filled, demonstrating the high level of interest.」

「Following the publication of this paper, a large number of facilities are considering introducing Electrolyzed Water Hemodialysis, and we believe that data collection will accelerate further as the number of adopting facilities increases.」

「In January this year, we published the results of the 5-year prognosis study conducted with Tohoku University in Scientific Reports, a British scientific journal published by the Nature Publishing Group. The paper reported that Electrolyzed Water Hemodialysis® reduced the risk of death and cerebrocardiovascular disease in dialysis patients by 41% compared with conventional dialysis, including congestive heart failure, ischemic heart disease, stroke and lower-limb amputation due to ischemia. It also reported improvements in post-dialysis hypertension and a reduction in the daily dosage of antihypertensive medication required.」

「The results are scheduled to be presented at the American Society of Nephrology on 2 November, and the paper is currently under submission. In September this year, a paper on the first-year interim analysis of the study passed rigorous peer review and was published in the international academic journal “PLOS ONE.”」

「The results are scheduled to be presented at the American Society of Nephrology on 2 November, and the paper is currently under submission. In September this year, a paper on the first-year interim analysis of the study passed rigorous peer review and was published in the international academic journal “PLOS ONE.”」

「The 5-year prognosis study conducted since 2012 was completed last December. The first-year report was submitted as a joint paper to an international academic journal, and the results of the 5-year study were presented at the 62nd Annual Meeting of the Japanese Society for Dialysis Therapy held in June this year. The results showed that “Electrolyzed Water Dialysis®” reduced the risks of death and complications compared with conventional dialysis, indicating the possibility of extending life expectancy, and were highly favorable.」

「We have received a report that very favorable results have been obtained regarding the effects of electrolyzed water dialysis, and the results are scheduled to be presented at the Japanese Society for Dialysis Therapy in June this year.」

「In October this year, we established a joint research division with Tohoku University focused on electrolyzed water dialysis. Going forward, we will establish evidence through clinical research into symptoms such as fatigue and use it to promote further adoption of the electrolyzed water dialysis system.」

「At the annual scientific meeting of the Japanese Society for Dialysis Therapy held in Osaka in June this year, 6 presentations related to electrolyzed water dialysis were given. At the first corporate seminar, which we held for the first time, 250 people attended and standing room was required, demonstrating that interest in and awareness of electrolyzed water dialysis are steadily increasing.」

「The 5-year prognosis study currently under way has reached its third year. The first-year report included cases in which the required dose of antihypertensive medication was approximately 30% lower than with conventional dialysis, and reported that pruritus and fatigue, which worsened significantly with conventional dialysis, did not worsen with electrolyzed water dialysis.」