Clarification of the functions of electrolyzed hydrogen water and differentiation from other types of water

「In February this year, a paper resulting from joint research with the Faculty of Human Sciences at Waseda University was published in the Journal of Cellular and Molecular Medicine. It suggests that electrolyzed hydrogen-rich water may support the efficacy of anticancer drugs against certain cancer cells.」

「We are continuing the joint research chair Essential Healthcare Science with Kobe University, together with joint research with RIKEN, the University of Tokyo, Tohoku University, Waseda University, Tokai University and others to elucidate the effects and mechanisms of electrolyzed hydrogen-rich water and explore new business opportunities. Currently, 4 new papers are being submitted and 2 are being prepared for submission.」

「In R&D, we are continuing the joint research chair Essential Healthcare Science with Kobe University, together with joint research with RIKEN, Tohoku University, Waseda University and others to elucidate the effects and mechanisms of electrolyzed hydrogen-rich water and explore new business opportunities. In October this year, a paper on the development of new electrode catalysts, based on the results of joint research with the University of Tokyo, was published in the Royal Society of Chemistry's Journal of Materials Chemistry A, with an impact factor of 10.7 (2023).」

「In January this year, we published a review paper in MDPI's Antioxidants journal on the results of comprehensive kidney-disease research involving electrolyzed hydrogen-rich water conducted since 2006 with the Graduate School of Medicine at Tohoku University and St. Luke's International Hospital. We also published a paper in the same journal with Kochi University School of Medicine and Susaki, Kochi Prefecture, on the ability of regular consumption of electrolyzed hydrogen-rich water to reduce waist circumference, an indicator of visceral fat in people with metabolic syndrome and those at risk of developing it. In March, we published another review paper in the same journal with RIKEN based on our research to date on the diverse benefits of electrolyzed hydrogen-rich water, including antioxidant, anti-inflammatory, analgesic, anti-fatigue, anti-cell-death, antidiabetic and antitumor effects. Currently, 4 new papers are being submitted and 2 are being prepared for submission.」

「In R&D, we are continuing the joint research chair Essential Healthcare Science with Kobe University, together with joint research with RIKEN, the University of Tokyo, Tohoku University, Waseda University and others to elucidate the effects and mechanisms of electrolyzed hydrogen-rich water and explore new business opportunities. A special issue on hydrogen is currently soliciting papers for the journal Antioxidants, published by MDPI, an academic publisher headquartered in Switzerland, and 2 papers related to our company have been accepted, with releases planned shortly. A further 5 papers are scheduled for submission to the journal, and 3 joint papers with the University of Tokyo and Waseda University are also being prepared. We will issue releases sequentially once they are published.」

「In R&D, we established the joint research chair Essential Healthcare Science with Kobe University in April this year. We are also continuing joint research with RIKEN, the University of Tokyo, Tohoku University, Waseda University and others to elucidate the effects and mechanisms of electrolyzed hydrogen-rich water and explore new business opportunities. At present, 1 paper is being submitted, and we plan to submit 4 papers during the current fiscal year.」

「In April this year, with the aim of further developing these results, we established the joint research chair Essential Healthcare Science with Kobe University. The three-year epidemiological study with Susaki, Kochi Prefecture, on health-check data and medical expenses associated with drinking electrolyzed hydrogen-rich water is continuing and is scheduled to end around the end of the fiscal year ending March 2025.」

「In November last year, a joint paper with RIKEN stating that regular, continued consumption of electrolyzed hydrogen-rich water keeps blood oxidative stress low even in healthy people was published in the multidisciplinary scientific journal Heliyon.」

「In R&D, we are pursuing joint research with RIKEN, the University of Tokyo, Tohoku University and others to elucidate the effects and mechanisms of electrolyzed hydrogen-rich water and explore new business opportunities. In October this year, a joint paper with RIKEN was published in the scientific journal Nutrients. The paper suggests that regular consumption of electrolyzed hydrogen-rich water suppresses intestinal inflammation and may help relieve the symptoms of inflammatory bowel disease. Inflammatory bowel disease is caused by intestinal inflammation and involves recurring symptoms such as diarrhea, bloody stools, abdominal pain and fatigue. The patient populations for ulcerative colitis, a designated intractable disease and a typical form of the condition, and Crohn's disease are 140,574 and 47,633, respectively (Ministry of Health, Labour and Welfare, FY2020 Health Administration Reports). As improvement in these patients' quality of life is expected, we will consider human trials going forward. We have published 4 papers this fiscal year, including this paper, and are currently submitting 1 additional joint paper with RIKEN.」

「In R&D, we are actively pursuing joint research with RIKEN, the University of Tokyo, Tohoku University, Waseda University, Tokai University and others, aimed at elucidating the effects and mechanisms of electrolyzed hydrogen-rich water and exploring new business opportunities. Currently, 3 papers, including 2 joint papers with RIKEN, are being submitted.」

「In May last year, a joint paper with Waseda University on the ability of electrolyzed hydrogen-rich water to suppress alcohol-induced liver-cell damage and the mechanism of action was published in the scientific journal Antioxidants. …In addition, 4 papers, including 2 joint papers with RIKEN, are currently being submitted as potentially strong evidence elucidating the effects of drinking electrolyzed hydrogen-rich water on health maintenance and improvement and disease prevention, and we will consider further deepening this research.」

「In 2022, including joint research with RIKEN, we plan to publish or submit a total of 7 papers and will work to strengthen our research structure, with obtaining certification for new indications and effects also in view.」

「In May this year, a joint paper with Waseda University on the ability of electrolyzed hydrogen-rich water to suppress alcohol-induced damage to cultured liver cells and the mechanism of action was published in the scientific journal Antioxidants. In July, a joint paper with Tohoku University showing that drinking electrolyzed hydrogen-rich water improves high insulin resistance in patients with type 2 diabetes was published in the English-language journal of the Japan Diabetes Society, Diabetology International. We currently plan to submit 5 joint papers during this fiscal year on the effects of drinking electrolyzed hydrogen-rich water, including research with RIKEN and Tohoku University.」

「In April last year, a joint paper with Ritsumeikan University showing that consumption of electrolyzed hydrogen-rich water significantly reduces energy expenditure during endurance exercise in hot conditions was published in the leading international physiology journal Temperature. In joint research with the University of Tokyo's Institute for Future Initiatives, a paper on the potential effects of electrolyzed hydrogen-rich water was published in June last year in the Nature-series scientific journal Scientific Reports. In joint research with RIKEN, we published a paper in the scientific journal BBRC showing that drinking electrolyzed hydrogen-rich water strengthens stress resilience. As this fiscal year is the final year of the five-year plan, papers are also being prepared from other ongoing research.」

「In December 2020, we jointly published a paper with RIKEN in the scientific journal BBRC (Biochemical and Biophysical Research Communications) showing that drinking electrolyzed hydrogen-rich water strengthens stress resilience. …In the current fiscal year, we plan to submit a total of 9 papers, including 3 joint papers already published with RIKEN, the Graduate School of the University of Tokyo and Ritsumeikan University, further strengthening the evidence and linking it to water ionizer sales.」

「In R&D, a joint paper with the College of Sport and Health Science at Ritsumeikan University was published in April in the leading international physiology journal Temperature, and a joint paper with the Graduate School of Engineering at the University of Tokyo was published in June in the British scientific journal Scientific Reports. In addition to the joint paper on diabetes with Tohoku University that is currently being submitted, we plan to submit 7 papers during the current fiscal year, including joint papers with RIKEN.」

「In April this year, a joint paper with the College of Sport and Health Science at Ritsumeikan University was published in the leading international physiology journal Temperature. It addressed the reduction in energy expenditure during endurance exercise in hot conditions through consumption of electrolyzed hydrogen-rich water. In June, a joint paper with the Graduate School of Engineering at the University of Tokyo showing that the electrodes in our water ionizers have very high hydrogen-generation efficiency was published in the British scientific journal Scientific Reports. In addition, 7 joint papers with RIKEN, Tohoku University and others are scheduled for submission during this fiscal year. We believe that stronger evidence and greater awareness of electrolyzed hydrogen-rich water will provide significant support for expanding the adoption of water ionizers.」

「In joint research with RIKEN, we are comprehensively pursuing basic, animal and clinical studies aimed at elucidating the mechanisms underlying the effects of electrolyzed hydrogen-rich water, and are currently preparing 2 papers. In the clinical trial involving diabetes patients and the consumption of electrolyzed hydrogen-rich water with the Graduate School of Medicine at Tohoku University, additional data have been collected and the paper is being submitted to an international academic journal. A paper from research with the Graduate School of Engineering at the University of Tokyo aimed at elucidating the physical properties of electrolyzed hydrogen-rich water is also being submitted and is expected to be published in June. With Susaki, Kochi Prefecture, we are conducting a three-year epidemiological study involving 300 households on health-check data and medical expenses associated with drinking electrolyzed hydrogen-rich water, and are currently recruiting participants.」

「This year, as a result of industry-academia joint research with RIKEN, Tohoku University and the University of Tokyo, among others, we plan to publish at least 5 papers on electrolyzed hydrogen-rich water, including papers on the effects of drinking it on diabetes and the mechanisms underlying its antioxidant properties. We believe that greater awareness of electrolyzed hydrogen-rich water and stronger evidence will significantly accelerate the adoption of water ionizers.」

「We are actively pursuing industry-government-academia joint research, including research with the Graduate School of Medicine at Tohoku University on the effects of drinking electrolyzed hydrogen-rich water on diabetes, for which a paper is currently being submitted to an international academic journal; comprehensive research on electrolyzed hydrogen-rich water with RIKEN; research with the Graduate School of Engineering at the University of Tokyo to elucidate its mechanisms; and research with Kochi University School of Medicine and Susaki, Kochi Prefecture, on the effects of drinking it on lifestyle-related diseases, together with a demonstration project on its impact on medical expenses.」

「In joint research with RIKEN aimed at elucidating the mechanisms underlying the effects of electrolyzed hydrogen-rich water, basic, animal and human studies are being actively conducted in parallel. As part of the results, the anti-fatigue effects of electrolyzed hydrogen-rich water were presented at the 15th Annual Meeting of the Japanese Society of Fatigue Science in May this year. The results of the clinical trial on lifestyle-related diseases involving consumption of electrolyzed hydrogen-rich water in Susaki, Kochi Prefecture, are expected to be compiled by the end of this year. Since August, we have also been conducting an epidemiological study with the city involving the collection and analysis of health-check data and a survey of medical expenses for residents of 500 households equipped with water ionizers.」

「In R&D, the results of the clinical trial involving diabetes patients and the consumption of electrolyzed hydrogen-rich water with Tohoku University School of Medicine are being submitted as a paper to an international academic journal. We are also preparing a paper on the results of joint research with the Graduate School of Engineering at the University of Tokyo on the physical properties of electrolyzed hydrogen-rich water. Joint research with RIKEN and clinical research in Susaki, Kochi Prefecture, are also progressing steadily. To promote the adoption of water ionizers, we will continue to strengthen cooperation with research institutions and advance our research.」

「In R&D, joint research with RIKEN aimed at elucidating the mechanisms underlying the effects of electrolyzed hydrogen-rich water, as well as a clinical trial on lifestyle-related diseases involving its consumption in Susaki, Kochi Prefecture, is making steady progress. For the clinical trial involving diabetes patients and the consumption of electrolyzed hydrogen-rich water with Tohoku University School of Medicine, a paper is being prepared for submission around January next year. A paper is also being prepared on the results of joint research with the Graduate School of Engineering at the University of Tokyo on the physical properties of electrolyzed hydrogen-rich water, with submission to an international academic journal with an extremely high impact factor planned for around April next year.」

「In R&D, joint research with RIKEN aimed at elucidating the mechanisms underlying the effects of electrolyzed hydrogen-rich water, as well as a clinical trial on lifestyle-related diseases involving its consumption in Susaki, Kochi Prefecture, is making steady progress.」

「In R&D, joint research with RIKEN aimed at elucidating the mechanisms underlying the effects of electrolyzed hydrogen-rich water is making steady progress. Recruitment of participants for a clinical trial on lifestyle-related diseases involving the consumption of electrolyzed hydrogen-rich water in Susaki, Kochi Prefecture, is also being actively conducted. Data analysis is under way for the clinical trial on diabetes at Tohoku University.」

「As higher levels of evidence are being sought, we followed the joint research with RIKEN, begun in June last year to elucidate the mechanisms of electrolyzed hydrogen-rich water, by starting a large-scale clinical trial of drinking electrolyzed hydrogen-rich water in Susaki, Kochi Prefecture, in November last year.」

「To achieve this at an early stage, we are actively advancing the joint research with RIKEN on elucidating the mechanisms underlying the effects of electrolyzed hydrogen-rich water, which began in June this year, as well as a public-private joint project scheduled to start in November in Susaki, Kochi Prefecture, to collect and analyze data from drinking tests involving residents and survey their medical expenses, and a clinical trial involving diabetes patients with Tohoku University.」

「In June this year, to further clarify the effects of drinking electrolyzed hydrogen-rich water, we commenced full-scale joint research with RIKEN, the National Institute of Physical and Chemical Research, on the theme of elucidating the mechanisms underlying its effects. The study will make comprehensive use of basic, animal and clinical research over a five-year period ending in March 2034.」

「In February this year, we jointly published a paper in the US scientific journal PLOS ONE with the Faculty of Agriculture at Kyushu University and the Graduate School of Engineering at the University of Tokyo showing that electrolyzed hydrogen-rich water has approximately five times the intracellular reactive oxygen species-scavenging capacity of bubbled hydrogen-rich water with the same dissolved hydrogen content, and that approximately 60% of this capacity remains even after the hydrogen has been removed from electrolyzed hydrogen-rich water.」

「We plan to provide 500 electrolyzed hydrogen-rich water ionizers in Susaki, Kochi Prefecture, and, with the cooperation of Kochi University School of Medicine, conduct a public-private joint project starting in May this year to collect and analyze data from drinking tests involving residents who consume electrolyzed hydrogen-rich water regularly, as well as survey their medical expenses. As part of this project, we also plan to begin a clinical drinking trial of electrolyzed hydrogen-rich water during the current fiscal year involving people with metabolic syndrome and those at risk of developing it. Kochi University School of Medicine is currently conducting a human study involving consumption of electrolyzed hydrogen-rich water as a pilot trial for this clinical research, which we believe will provide one piece of evidence regarding its effects in humans. A clinical drinking trial involving diabetes patients with Tohoku University School of Medicine is also progressing smoothly and is scheduled to be completed this year. In basic research, a joint paper with the Faculty of Agriculture at Kyushu University and the Graduate School of Engineering at the University of Tokyo, addressing the superiority of electrolyzed hydrogen-rich water over hydrogen-rich water generated by bubbling, is expected to be published in February this year.」

「We have decided to provide electrolyzed hydrogen-rich water ionizers to 500 households (planned) in Susaki, Kochi Prefecture, and, with the cooperation of Kochi University School of Medicine, conduct a public-private joint project to collect and analyze data from drinking tests involving residents who consume electrolyzed hydrogen-rich water regularly, as well as survey their medical expenses. We are preparing for a start next May.」

「In addition to further elucidating the functions of electrolyzed hydrogen-rich water, we will pursue and communicate the differences between electrolyzed hydrogen-rich water and hydrogen-rich water generated by methods such as gas bubbling, thereby expanding the water ionizer market and achieving significant growth in our business.」

「We are conducting basic research with the University of Tokyo, Kyushu University and others to differentiate our electrolyzed hydrogen-rich water from other types of water, including hydrogen water produced through bubbling. We are also pursuing clinical research to verify its effects on diabetes and metabolic syndrome, alongside application research in hemodialysis, where clinical studies are already progressing and practical use is within reach.」