HMT, based in Yamagata Prefecture, is presenting a new evidence base for cosmetics development using its proprietary metabolomics analysis, while advancing molecular-level evaluation and the development of more sophisticated raw materials. Going forward, it aims to expand evaluation systems that integrate lipidomics and distinguish differences among the molecular species of ceramides and fatty acids.
As evidence-based development advances in the cosmetics and healthcare sectors, Human Metabolome Technologies, Inc. (HMT) is using its proprietary metabolite analysis to provide a logical, molecular-level evidence base and support the emerging convergence of wellness and beauty. Under the leadership of Ohata Yasuhiro (大畑 恭宏), the company uses comprehensive metabolite profiling to visualize useful metabolites from the early stages, making it possible to link the findings directly to materials development and improvements in fermentation processes.
The comprehensive metabolite profiling provided by the company tracks the dynamics of several hundred to 1,000 metabolites occurring in cells and skin tissue, capturing changes across entire metabolic networks that are difficult to detect through individual components alone. By combining non-invasive and minimally invasive evaluation methods with analysis of molecular mechanisms, the company measures amino acids and lipid metabolites from stratum corneum collected through tape stripping, clarifying changes in barrier function and moisturization mechanisms at the molecular level.
In addition, through raw-materials development leveraging autophagy activity assessment and exosome purification, the company provides evidence for mechanisms of cellular repair that have traditionally been difficult to demonstrate. It also contributes to elucidating individual differences through human studies and to the discovery of biomarkers. Going forward, it aims to expand evaluation systems that integrate metabolomics and lipidomics analyses and identify fine differences among the molecular species of ceramides and fatty acids.
HMT plans to strengthen its support for personalized cosmetics development and its high-precision human study design services while working to enhance the credibility of the wellness industry. Its future research and development is aimed at applying these capabilities to a broader range of wellness fields by providing objective, data-based indicators.