Japan Women’s University announced that it had developed OddCAPS, a new method for detecting DNA mutations at low cost. The method can be applied to sequences that were previously difficult to analyze and can be performed without specialized equipment. The findings were also published in a journal of the Genetics Society of America.
A group at Japan Women’s University announced that it had developed a new, low-cost method for genetic analysis to detect DNA mutations. The method, called OddCAPS, can also be applied to specific DNA sequences.
The new method significantly relaxes the constraints imposed by conventional restriction enzymes, demonstrating that a single nucleotide in any DNA sequence can be detected using 8 common restriction enzymes.
The method does not require specialized analytical equipment and can be performed using standard PCR and electrophoresis equipment. It is therefore expected to serve as a low-cost, versatile analytical technology for a wide range of research applications, including the selection of mutants and genetic analysis.
The method was developed by a group from the Laboratory of Biological Responses in the Department of Chemical and Biological Sciences, Faculty of Science, at the university. The research findings were also published in a journal of the Genetics Society of America.