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Other Disclosures4978ReproCELL IncorporatedMaterials and Chemicals

Notice of the Commencement of Manufacturing and Sales of Neoantigen-Derived Peptides

ReproCELL Incorporated has entered into a master services agreement with HLB Pep, establishing a framework to sell in Japan and overseas neoantigen-derived peptides manufactured at HLB Pep's GMP-compliant facilities. The company has added peptide manufacturing based on detection results to its existing neoantigen detection service, “NeoSite.”

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Improvement
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Announced details

Neoantigen-derived peptidesNeoantigen detection service “NeoSite”
Applicable field (uses covered by this announcement)
Personalized cancer vaccinesT-cell receptor (TCR) therapiesResearch on immune cell therapiesTranslational researchTreatment design in clinical development
Launch dateThe commencement of manufacturing and sales was announced on 23 March 2026. The actual service commencement date, and whether this represents a planned or completed start, are not disclosed.
Contract DateEntered into on or before 23 March 2026; the specific date is not disclosed
Relationship between the counterparty and the company
ReproCELL Incorporated4978
Relationship with the Company

The parties have entered into a master services agreement. HLB Pep will manufacture peptides at its GMP-compliant facilities, and ReproCELL Incorporated will sell them in Japan and global markets under a collaboration arrangement. Capital and personnel relationships are not disclosed.

CounterpartyHLB Pep

A Korean biotechnology company with strengths in the development and manufacture of peptide materials and peptide drugs. It provides contract development and manufacturing services (CDMO) for peptides used as active pharmaceutical ingredients (APIs) at its own GMP-compliant manufacturing facilities. Its location, representative, capital and year of establishment are not disclosed.

Location (as indicated in this announcement)

HLB Pep's own GMP-compliant manufacturing facilities; the location beyond the fact that it is a Korean company is not disclosed

Impact on Business Performance

The direct impact on the company's results is expected to be minor. The company will promptly disclose any event that has a material impact.

The company does not address Contract Value / Offering price.

Announced details
ItemDetails
Names of Products / Services CoveredNeoantigen-derived peptides, Neoantigen detection service “NeoSite”
CounterpartyHLB Pep
Counterparty overviewA Korean biotechnology company with strengths in the development and manufacture of peptide materials and peptide drugs. It provides contract development and manufacturing services (CDMO) for peptides used as active pharmaceutical ingredients (APIs) at its own GMP-compliant manufacturing facilities. Its location, representative, capital and year of establishment are not disclosed.
Relationship with the CompanyThe parties have entered into a master services agreement. HLB Pep will manufacture peptides at its GMP-compliant facilities, and ReproCELL Incorporated will sell them in Japan and global markets under a collaboration arrangement. Capital and personnel relationships are not disclosed.
Contract DateEntered into on or before 23 March 2026; the specific date is not disclosed
Launch dateThe commencement of manufacturing and sales was announced on 23 March 2026. The actual service commencement date, and whether this represents a planned or completed start, are not disclosed.
Applicable areaPersonalized cancer vaccines, T-cell receptor (TCR) therapies, Research on immune cell therapies, Translational research, Treatment design in clinical development
LocationHLB Pep's own GMP-compliant manufacturing facilities; the location beyond the fact that it is a Korean company is not disclosed
Impact on Business PerformanceThe direct impact on the company's results is expected to be minor. The company will promptly disclose any event that has a material impact.
Items this document does not state (9)
Contract ValueOffering priceAward/certification nameAwarding / certifying bodyRegistration number and expiry dateLocation scaleQuantitative EffectsUsage historySource

These are items the company does not state in this document. We do not leave them blank, nor fill them in from other sources or by inference.

The reasons the company gives

The company's own explanation, not something inferred from the numbers.

To provide an integrated service covering everything from neoantigen detection through the manufacture of GMP-grade peptides based on the detection results, thereby supporting the research, development and implementation of personalized cancer immunotherapies.

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Notice of the Commencement of Manufacturing and Sales of Neoantigen-Derived Peptides | ReproCELL Incorporated (4978) timely disclosure | Komori