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Other Disclosures4890Tsubota Laboratory IncorporatedPharmaceuticals

[Paper] Polarization of choroidal macrophages regulates the onset and progression of myopia

A collaborative research paper with the Department of Ophthalmology, Keio University School of Medicine, whose first author is an employee of our company, was published in the international academic journal iScience. Mouse experiments demonstrated that the state of choroidal macrophages may affect the onset and progression of myopia.

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Announced details

Applicable field (uses covered by this announcement)

Understanding and treatment approaches for the onset and progression of myopia

Launch date27 April 2026 (date of announcement of the paper's publication)
Relationship between the counterparty and the company
Tsubota Laboratory Incorporated4890
Relationship with the Company

Joint Research

CounterpartyDepartment of Ophthalmology, Keio University School of Medicine
Location (as indicated in this announcement)

Shinjuku-ku, Tokyo (our company headquarters)

In this announcement the company addresses none of Contract Value / Offering price / Impact on Business Performance.

Source (materials cited by the company)

International academic journal iScience, DOI: 10.1016/j.isci.2026.115764

Announced details
ItemDetails
CounterpartyDepartment of Ophthalmology, Keio University School of Medicine
Relationship with the CompanyJoint Research
Launch date27 April 2026 (date of announcement of the paper's publication)
Applicable areaUnderstanding and treatment approaches for the onset and progression of myopia
LocationShinjuku-ku, Tokyo (our company headquarters)
SourceInternational academic journal iScience, DOI: 10.1016/j.isci.2026.115764
Items this document does not state (12)
Names of Products / Services CoveredCounterparty overviewContract ValueOffering priceContract DateAward/certification nameAwarding / certifying bodyRegistration number and expiry dateLocation scaleQuantitative EffectsUsage historyImpact on Business Performance

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The reasons the company gives

The company's own explanation, not something inferred from the numbers.

To investigate the effects of choroidal macrophage polarization on the progression of myopia and demonstrate the potential for new approaches to understanding and treating myopia.

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[Paper] Polarization of choroidal macrophages regulates the onset and progression of myopia | Tsubota Laboratory Incorporated (4890) timely disclosure | Komori