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Other Disclosures4889Renascience Inc.Pharmaceuticals

Notice of the commencement of a Phase I clinical trial at Saudi Arabia’s King Abdullah International Medical Research Center (KAIMRC)

A clinical trial agreement has been signed with KAIMRC, and a Phase 1 clinical trial of the PAI-1 inhibitor RS5614 will commence in Saudi Arabia. Subject enrollment and the trial are scheduled to be completed by the end of December 2026, followed by preparation of the final report.

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Announced details

PAI-1 inhibitor RS5614
Applicable field (uses covered by this announcement)

Anti-aging and longevity therapeutics; evaluation of safety and tolerability

Launch dateIt was decided that the trial would commence as of the announcement on 21 July 2026. The specific trial commencement date is Not disclosed
Contract Date21 July 2026 (the date on which the signing of the clinical trial agreement was announced; the agreement execution date itself is Not disclosed)
Relationship between the counterparty and the company
Renascience Inc.4889
Relationship with the Company

A basic agreement has been signed covering the clinical development, joint research and commercialization of RS5614 in Saudi Arabia. A clinical trial agreement has now been signed.

CounterpartyKing Abdullah International Medical Research Center (KAIMRC)

A medical research institution of the Saudi Arabian government

Location (as indicated in this announcement)

KAIMRC (Saudi Arabia)

Impact on Business Performance

The impact on results for the current fiscal year is currently expected to be minor. If any matters requiring disclosure arise, they will be disclosed promptly.

The company does not address Contract Value / Offering price.

Announced details
ItemDetails
Names of Products / Services CoveredPAI-1 inhibitor RS5614
CounterpartyKing Abdullah International Medical Research Center (KAIMRC)
Counterparty overviewA medical research institution of the Saudi Arabian government
Relationship with the CompanyA basic agreement has been signed covering the clinical development, joint research and commercialization of RS5614 in Saudi Arabia. A clinical trial agreement has now been signed.
Contract Date21 July 2026 (the date on which the signing of the clinical trial agreement was announced; the agreement execution date itself is Not disclosed)
Launch dateIt was decided that the trial would commence as of the announcement on 21 July 2026. The specific trial commencement date is Not disclosed
Applicable areaAnti-aging and longevity therapeutics; evaluation of safety and tolerability
LocationKAIMRC (Saudi Arabia)
Impact on Business PerformanceThe impact on results for the current fiscal year is currently expected to be minor. If any matters requiring disclosure arise, they will be disclosed promptly.
Items this document does not state (9)
Contract ValueOffering priceAward/certification nameAwarding / certifying bodyRegistration number and expiry dateLocation scaleQuantitative EffectsUsage historySource

These are items the company does not state in this document. We do not leave them blank, nor fill them in from other sources or by inference.

The reasons the company gives

The company's own explanation, not something inferred from the numbers.

The trial is being commenced as a concrete initiative to advance the clinical evaluation of RS5614 in Saudi Arabia, based on the basic agreement signed on 6 October 2025.

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Notice of the commencement of a Phase I clinical trial at Saudi Arabia’s King Abdullah International Medical Research Center (KAIMRC) | Renascience Inc. (4889) timely disclosure | Komori