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Other Disclosures4882Perseus Proteomics Inc.Pharmaceuticals

Notice of Publication of a Co-authored Paper with Tokyo University of Pharmacy and Life Sciences on Findings Elucidating the SLC46A3-Mediated Drug Transport Function Using Our Research Reagent, Anti-MMAE Antibody

A co-authored paper with Tokyo University of Pharmacy and Life Sciences on research conducted using our “anti-MMAE antibody” research reagent was published online in the international scientific journal Molecular Pharmaceutics. The paper elucidates the function of SLC46A3 in transporting auristatin derivatives from lysosomes to the cytoplasm.

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Announced details

Anti-MMAE antibody
Applicable field (uses covered by this announcement)

Intracellular transport of active metabolites of antibody-drug conjugates, and research on the mechanisms of drug efficacy and resistance in breast cancer therapies

Relationship between the counterparty and the company
Perseus Proteomics Inc.4882
Relationship with the Company

Co-researcher for the co-authored paper with Tokyo University of Pharmacy and Life Sciences. The paper lists the Laboratory of Pharmacokinetic Control, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, and 株式会社ペルセウスプロテオミクス as authors.

CounterpartyTokyo University of Pharmacy and Life Sciences

Laboratory of Pharmacokinetic Control, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences. Other locations, representative, capital, and year established: Not disclosed

Registration number and expiry date

DOI: 10.1021/acs.molpharmaceut.6c00535

In this announcement the company addresses none of Contract Value / Offering price / Impact on Business Performance.

Source (materials cited by the company)

Molecular Pharmaceutics

Announced details
ItemDetails
Names of Products / Services CoveredAnti-MMAE antibody
CounterpartyTokyo University of Pharmacy and Life Sciences
Counterparty overviewLaboratory of Pharmacokinetic Control, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences. Other locations, representative, capital, and year established: Not disclosed
Relationship with the CompanyCo-researcher for the co-authored paper with Tokyo University of Pharmacy and Life Sciences. The paper lists the Laboratory of Pharmacokinetic Control, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, and 株式会社ペルセウスプロテオミクス as authors.
Applicable areaIntracellular transport of active metabolites of antibody-drug conjugates, and research on the mechanisms of drug efficacy and resistance in breast cancer therapies
Registration number and expiry dateDOI: 10.1021/acs.molpharmaceut.6c00535
SourceMolecular Pharmaceutics
Items this document does not state (11)
Contract ValueOffering priceContract DateLaunch dateAward/certification nameAwarding / certifying bodyLocationLocation scaleQuantitative EffectsUsage historyImpact on Business Performance

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The reasons the company gives

The company's own explanation, not something inferred from the numbers.

To disclose research findings elucidating SLC46A3’s drug transport function using the anti-MMAE antibody developed and commercialized by our company.

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Notice of Publication of a Co-authored Paper with Tokyo University of Pharmacy and Life Sciences on Findings Elucidating the SLC46A3-Mediated Drug Transport Function Using Our Research Reagent, Anti-MMAE Antibody | Perseus Proteomics Inc. (4882) timely disclosure | Komori