Announced details
Inhibition of colorectal cancer growth and prevention of liver metastasis; prevention and treatment of peritoneal dissemination of gastric cancer
In mouse models, inhibition of colorectal cancer growth, prevention of liver metastasis and peritoneal dissemination of gastric cancer, and a substantial extension of survival in a gastric cancer peritoneal dissemination model were confirmed (specific figures: Not disclosed).
Joint research under the study titled “Investigation of the Therapeutic Effects of Cancer-Specific Antibodies in Solid Cancer Models”
The authors are affiliated with the Division of Gastrointestinal Surgery, Department of General Surgical Science, Gunma University Graduate School of Medicine; the Division of Gene Therapy, Future Advanced Research Institute, Research Division of Integrative Oncology, Gunma University; and the Division of Hepato-Biliary-Pancreatic Surgery, Department of General Surgical Science, Gunma University Graduate School of Medicine.
In this announcement the company addresses none of Contract Value / Offering price / Impact on Business Performance.
Signal Transduction and Targeted Therapy (paper title: Clinical-stage human anti-transferrin receptor antibody suppresses colorectal cancer metastasis; DOI: 10.1038/s41392-026-02917-9)
| Item | Details |
|---|---|
| Names of Products / Services Covered | PPMX-T003 (anti-transferrin receptor 1 (TfR1) antibody) |
| Counterparty | National University Corporation Gunma University |
| Counterparty overview | The authors are affiliated with the Division of Gastrointestinal Surgery, Department of General Surgical Science, Gunma University Graduate School of Medicine; the Division of Gene Therapy, Future Advanced Research Institute, Research Division of Integrative Oncology, Gunma University; and the Division of Hepato-Biliary-Pancreatic Surgery, Department of General Surgical Science, Gunma University Graduate School of Medicine. |
| Relationship with the Company | Joint research under the study titled “Investigation of the Therapeutic Effects of Cancer-Specific Antibodies in Solid Cancer Models” |
| Applicable area | Inhibition of colorectal cancer growth and prevention of liver metastasis; prevention and treatment of peritoneal dissemination of gastric cancer |
| Quantitative Effects | In mouse models, inhibition of colorectal cancer growth, prevention of liver metastasis and peritoneal dissemination of gastric cancer, and a substantial extension of survival in a gastric cancer peritoneal dissemination model were confirmed (specific figures: Not disclosed). |
| Source | Signal Transduction and Targeted Therapy (paper title: Clinical-stage human anti-transferrin receptor antibody suppresses colorectal cancer metastasis; DOI: 10.1038/s41392-026-02917-9) |
Items this document does not state (11)
These are items the company does not state in this document. We do not leave them blank, nor fill them in from other sources or by inference.
The reasons the company gives
The company's own explanation, not something inferred from the numbers.The results of the joint research conducted by our company and Gunma University have been published online in the academic journal Signal Transduction and Targeted Therapy. The study reported preclinical findings indicating that PPMX-T003 may inhibit metastasis and peritoneal dissemination of colorectal and gastric cancer.