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Other Disclosures4596Kubota Pharmaceutical Holdings Co.,Ltd.Pharmaceuticals

Notice Regarding the Presentation of Subgroup Analysis Results from a Phase 3 Clinical Trial of Emixustat Hydrochloride at the ARVO (Association for Research in Vision and Ophthalmology) 2026 Annual Meeting

At ARVO 2026, we plan to present subgroup analysis results from the Phase 3 trial of emixustat hydrochloride. Although the primary endpoint did not reach statistical significance in the overall population, lesion progression was significantly inhibited in patients with relatively small lesions.

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Announced details

Emixustat hydrochloride (emixustat)
Applicable field (uses covered by this announcement)

Treatment of macular atrophy associated with Stargardt disease

Launch date7 May 2026, from 8:00 a.m. to 9:45 a.m. (scheduled; poster presentation)
What the company reported numerically
Quantitative Effects

Lesion progression was significantly inhibited in patients with relatively small lesions at baseline

Relationship between the counterparty and the company
Kubota Pharmaceutical Holdings Co.,Ltd.4596
Relationship with the Company

Dr. Kubota Ryo (窪田良), the Company's representative director, chairman, president and CEO, is scheduled to present at the organization's Annual Meeting

CounterpartyARVO (Association for Research in Vision and Ophthalmology)

A leading global academic organization for ophthalmic research, with approximately 12,000 members in more than 75 countries

Location (as indicated in this announcement)

Colorado Convention Center (Denver, Colorado, U.S.)

In this announcement the company addresses none of Contract Value / Offering price / Impact on Business Performance.

Source (materials cited by the company)

ARVO (Association for Research in Vision and Ophthalmology) 2026 Annual Meeting

Announced details
ItemDetails
Names of Products / Services CoveredEmixustat hydrochloride (emixustat)
CounterpartyARVO (Association for Research in Vision and Ophthalmology)
Counterparty overviewA leading global academic organization for ophthalmic research, with approximately 12,000 members in more than 75 countries
Relationship with the CompanyDr. Kubota Ryo (窪田良), the Company's representative director, chairman, president and CEO, is scheduled to present at the organization's Annual Meeting
Launch date7 May 2026, from 8:00 a.m. to 9:45 a.m. (scheduled; poster presentation)
Applicable areaTreatment of macular atrophy associated with Stargardt disease
LocationColorado Convention Center (Denver, Colorado, U.S.)
Quantitative EffectsLesion progression was significantly inhibited in patients with relatively small lesions at baseline
SourceARVO (Association for Research in Vision and Ophthalmology) 2026 Annual Meeting
Items this document does not state (9)
Contract ValueOffering priceContract DateAward/certification nameAwarding / certifying bodyRegistration number and expiry dateLocation scaleUsage historyImpact on Business Performance

These are items the company does not state in this document. We do not leave them blank, nor fill them in from other sources or by inference.

The reasons the company gives

The company's own explanation, not something inferred from the numbers.

The subgroup analysis results from the Phase 3 clinical trial will be presented at the ARVO 2026 Annual Meeting. Based on the analysis results, Kubota Vision, the Company's U.S. subsidiary, believes that emixustat could be a promising treatment option for patients with early-stage Stargardt disease and will continue to explore development opportunities.

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Notice Regarding the Presentation of Subgroup Analysis Results from a Phase 3 Clinical Trial of Emixustat Hydrochloride at the ARVO (Association for Research in Vision and Ophthalmology) 2026 Annual Meeting | Kubota Pharmaceutical Holdings Co.,Ltd. (4596) timely disclosure | Komori