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Statutory disclosure document4583Chiome Bioscience Inc.Pharmaceuticals

Notice Regarding the Grant of a U.S. Patent for the Combination of a Humanized DLK-1 Antibody and Lenvatinib

We received a notice of allowance for a U.S. patent application concerning the combination of a humanized DLK-1 antibody and lenvatinib. This advances the acquisition of U.S. intellectual property rights for combination therapies involving antibodies including CBA-1205.

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Decision and Details

U.S. patent allowance for a pharmaceutical for cancer treatment

Decision25 September 2026 (date the notice of allowance was received)
Going forwardFor CBA-1205, we aim to out-license the product to pharmaceutical companies using safety and preliminary efficacy data obtained from a domestic Phase 1 clinical trial.
Quantity / scaleU.S. patent application No.17/599,820
Reason

To strengthen the intellectual property foundation supporting our development and out-licensing activities.

Impact on Business Performance

This matter will have no impact on results for the fiscal year ending December 2026.

Title of inventionPharmaceutical for cancer treatment
Patent holderChiome Bioscience Inc.
Decision and Details
ItemDetails
Matter CoveredU.S. patent allowance for a pharmaceutical for cancer treatment
Decision Date25 September 2026 (date the notice of allowance was received)
Quantity / scaleU.S. patent application No.17/599,820
Impact on Business PerformanceThis matter will have no impact on results for the fiscal year ending December 2026.
ReasonTo strengthen the intellectual property foundation supporting our development and out-licensing activities.
Future plansFor CBA-1205, we aim to out-license the product to pharmaceutical companies using safety and preliminary efficacy data obtained from a domestic Phase 1 clinical trial.
Title of inventionPharmaceutical for cancer treatment
Patent holderChiome Bioscience Inc.
Items this document does not state (6)
Decision-Making BodyImplementation DatePeriod CoveredAmountGoverning RuleRelated previous disclosures

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The reasons the company gives

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To strengthen the intellectual property foundation supporting our development and out-licensing activities.

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Notice Regarding the Grant of a U.S. Patent for the Combination of a Humanized DLK-1 Antibody and Lenvatinib | Chiome Bioscience Inc. (4583) timely disclosure | Komori