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Business Alliances4582SymBio Pharmaceuticals LimitedPharmaceuticals

BCV Joint Research and Development Agreement (CRADA) with NIH/NINDS for Multiple Sclerosis Extended by Three Years; Development in Neurodegenerative Diseases Advanced Following Progressive Multifocal Leukoencephalopathy

The joint research and development agreement for BCV for multiple sclerosis with the National Institute of Neurological Disorders and Stroke (NINDS), part of the NIH, has been extended by three years, and research will continue through March 2029. Development of the route of administration and formulation will also proceed toward clinical trials.

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Agreements reached under this partnership

Business Alliances
4582SymBio Pharmaceuticals Limited
Alliance partnerNational Institute of Neurological Disorders and Stroke (NINDS)
Details of the alliance
  1. 1

    Evaluate the potential for anti-Epstein-Barr virus activity

  2. 2

    Obtain experimental evidence supporting its utility as an antiviral therapy for Epstein-Barr virus-associated multiple sclerosis

These are items that the documents state the two companies will work on. The lines above and below represent arrangements between the two companies.

About the partner
Business DescriptionThe National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health (NIH)
LocationUnited States
Impact on Business Performance

No impact on consolidated results for the fiscal year ending December 2026

Contract DateMarch 2023Alliance start dateMarch 2023 (start of joint research)Contract PeriodExtended by three years. The term of this CRADA has been extended through March 2029
Agreements reached under this partnership
ItemDetails
Name of alliance partnerNational Institute of Neurological Disorders and Stroke (NINDS)
Alliance partner's business activitiesThe National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health (NIH)
Alliance partner's locationUnited States
Type of allianceBusiness Alliances
Details of the allianceEvaluate the potential for anti-Epstein-Barr virus activity, Obtain experimental evidence supporting its utility as an antiviral therapy for Epstein-Barr virus-associated multiple sclerosis
Contract PeriodExtended by three years. The term of this CRADA has been extended through March 2029
Contract DateMarch 2023
Alliance start dateMarch 2023 (start of joint research)
Impact on Business PerformanceNo impact on consolidated results for the fiscal year ending December 2026
Items this document does not state (14)
Alliance partner's capitalAlliance partner's net salesAlliance partner's operating incomeNumber of shares acquiredAcquisition priceShareholding ratioOverview of the joint ventureOwnership ratioDispatch of directors and officersNumerical targets under the allianceShareholding PolicyDate of board resolutionShare Acquisition Date and Payment DateChange in major shareholders

These are items the company does not state in this document. We do not leave them blank, nor fill them in from other sources or by inference.

The reasons the company gives

The company's own explanation, not something inferred from the numbers.

Multiple sclerosis is a chronic disease, making the development of a more suitable route of administration and formulation important for bringing a treatment to practical use. In addition, based on the research results to date, the agreement will allow the efficacy in humans and the potential for clinical application to be evaluated through clinical trials.

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BCV Joint Research and Development Agreement (CRADA) with NIH/NINDS for Multiple Sclerosis Extended by Three Years; Development in Neurodegenerative Diseases Advanced Following Progressive Multifocal Leukoencephalopathy | SymBio Pharmaceuticals Limited (4582) timely disclosure | Komori