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Management planning4576D.Western Therapeutics Institute, Inc.Pharmaceuticals

Notice Regarding the Update to Matters Concerning the Business Plan and Growth Potential

The development pipeline schedule in the business plan was updated to add the development timeline in Japan for the glaucoma treatment H-1337. The updated plan calls for a small-scale dose-confirmation study in 2028 and the start of a Phase 3 trial from 2029 onward.

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Items stated in the management plan

Partially revised
Business Plan and Growth PotentialPlan period 2025–2028 (H-1337: 2029–start of Phase 3)
Publication date 3 September 2026
Key initiatives
01Include the development plan for H-1337
Plan assumptionsThe above plan is based on the development plan assumed by the licensing partner or the Company's projections and may differ from actual development progress.
Non-financial targetsIndicator name Development progress for H-1337 (glaucoma treatment, Japan) / Target value Small-scale dose-confirmation study, start of Phase 3 / Timing 2028, 2029 onward
Risks identified by the company
The above plan is based on the development plan assumed by the licensing partner or the Company's projections and may differ from actual development progress.
Reason for revision or withdrawal

As stated in the "Notice Concerning the Determination of the Domestic Development Plan for the Glaucoma Treatment H-1337" disclosed today, the development plan for H-1337 has been included.

Items stated in the management plan
ItemDetails
Plan nameBusiness Plan and Growth Potential
Plan period2025–2028 (H-1337: 2029–start of Phase 3)
Progress against the planPartially revised
Non-financial targetsIndicator name Development progress for H-1337 (glaucoma treatment, Japan) / Target value Small-scale dose-confirmation study, start of Phase 3 / Timing 2028, 2029 onward
Plan assumptionsThe above plan is based on the development plan assumed by the licensing partner or the Company's projections and may differ from actual development progress.
Key initiativesInclude the development plan for H-1337
Reason for revision or withdrawalAs stated in the "Notice Concerning the Determination of the Domestic Development Plan for the Glaucoma Treatment H-1337" disclosed today, the development plan for H-1337 has been included.
Risks identifiedThe above plan is based on the development plan assumed by the licensing partner or the Company's projections and may differ from actual development progress.
Publication date3 September 2026
Items this document does not state (16)
Sales TargetOperating profit targetOperating profit margin targetNet income targetROE targetROIC targetPayout ratio / DOE policyTreasury share acquisition policyCost of capitalSelf-assessment of PBR and share priceTotal investment planInvestment amount by sectorSegment targetResults under the previous planSize of the Target MarketDate of board resolution

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The reasons the company gives

The company's own explanation, not something inferred from the numbers.

The development plan for H-1337 was included based on the "Notice Concerning the Determination of the Domestic Development Plan for the Glaucoma Treatment H-1337" disclosed today.

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Notice Regarding the Update to Matters Concerning the Business Plan and Growth Potential | D.Western Therapeutics Institute, Inc. (4576) timely disclosure | Komori