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Other Disclosures4572Carna Biosciences,Inc.Pharmaceuticals

The investigator-initiated clinical trial of monzosertib at The University of Texas MD Anderson Cancer Center has been registered and published on ClinicalTrials.gov

A Phase 1b investigator-initiated clinical trial for patients with relapsed/refractory AML or high-risk MDS using monzosertib (AS-0141) has been registered and posted on ClinicalTrials.gov. The announcement indicates that preparations for the trial launch have progressed, not that the trial itself has started.

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54Recurring
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Improvement
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Announced details

monzosertib(AS-0141)
Applicable field (uses covered by this announcement)
Relapsed/refractory acute myeloid leukemia (AML)High-risk myelodysplastic syndromes (MDS)
Contract Date18 December 2025 (the date on which execution of the MOU was announced; the date the MOU itself was executed is Not disclosed)
Relationship between the counterparty and the company
Carna Biosciences,Inc.4572
Relationship with the Company

We are working with the Center to prepare for the start of the Phase 1b monzosertib trial led by the Center. The disclosure states that an MOU was executed on 18 December 2025.

CounterpartyThe University of Texas MD Anderson Cancer Center

The University of Texas MD Anderson Cancer Center in the United States. Other information on its location, representative, capital, year established and business activities is Not disclosed.

Registration number and expiry date

ClinicalTrials.gov ID: NCT07780565. The validity period is Not disclosed.

In this announcement the company addresses none of Contract Value / Offering price / Impact on Business Performance.

Source (materials cited by the company)

ClinicalTrials.gov

Announced details
ItemDetails
Names of Products / Services Coveredmonzosertib(AS-0141)
CounterpartyThe University of Texas MD Anderson Cancer Center
Counterparty overviewThe University of Texas MD Anderson Cancer Center in the United States. Other information on its location, representative, capital, year established and business activities is Not disclosed.
Relationship with the CompanyWe are working with the Center to prepare for the start of the Phase 1b monzosertib trial led by the Center. The disclosure states that an MOU was executed on 18 December 2025.
Contract Date18 December 2025 (the date on which execution of the MOU was announced; the date the MOU itself was executed is Not disclosed)
Applicable areaRelapsed/refractory acute myeloid leukemia (AML), High-risk myelodysplastic syndromes (MDS)
Registration number and expiry dateClinicalTrials.gov ID: NCT07780565. The validity period is Not disclosed.
SourceClinicalTrials.gov
Items this document does not state (10)
Contract ValueOffering priceLaunch dateAward/certification nameAwarding / certifying bodyLocationLocation scaleQuantitative EffectsUsage historyImpact on Business Performance

These are items the company does not state in this document. We do not leave them blank, nor fill them in from other sources or by inference.

The reasons the company gives

The company's own explanation, not something inferred from the numbers.

To indicate progress in preparations for initiating this Phase 1b trial.

How to read this page

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The investigator-initiated clinical trial of monzosertib at The University of Texas MD Anderson Cancer Center has been registered and published on ClinicalTrials.gov | Carna Biosciences,Inc. (4572) timely disclosure | Komori