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Other Disclosures4571Nano Holdings,Inc.Pharmaceuticals

NANO MRNA Development Pipeline: Notice Regarding Presentation of Phase I Trial Results for the Novel Nucleic Acid Drug “TUG1 ASO” for Recurrent Glioblastoma at AACR 2026

The Phase I trial of TUG1 ASO, a nucleic acid drug being jointly developed with Nagoya University for recurrent glioblastoma, has been completed, and Dose Level 3 was determined to be the maximum tolerated dose. Pharmacokinetic data were presented for the first time, and plans for the next Phase Ib trial, as well as the planned submission of a clinical trial notification to the PMDA (Pharmaceuticals and Medical Devices Agency), were disclosed.

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Announced details

TUG1 ASO
Applicable field (uses covered by this announcement)

Treatment of recurrent glioblastoma

What the company reported numerically
Usage history

2 patients were dosed at Dose Level 4 in the Phase I trial. Long-term Stable Disease and an unconfirmed Partial Response were observed in 1 patient at Dose Level 2.

Relationship between the counterparty and the company
Nano Holdings,Inc.4571
Relationship with the Company

The parties are jointly developing the drug. They have nearly reached agreement with the investigator-initiated clinical trial team on the protocol for the Phase Ib trial.

CounterpartyNagoya University

In this announcement the company addresses none of Contract Value / Offering price / Impact on Business Performance.

Source (materials cited by the company)

AACR 2026

Announced details
ItemDetails
Names of Products / Services CoveredTUG1 ASO
CounterpartyNagoya University
Relationship with the CompanyThe parties are jointly developing the drug. They have nearly reached agreement with the investigator-initiated clinical trial team on the protocol for the Phase Ib trial.
Applicable areaTreatment of recurrent glioblastoma
Usage history2 patients were dosed at Dose Level 4 in the Phase I trial. Long-term Stable Disease and an unconfirmed Partial Response were observed in 1 patient at Dose Level 2.
SourceAACR 2026
Items this document does not state (12)
Counterparty overviewContract ValueOffering priceContract DateLaunch dateAward/certification nameAwarding / certifying bodyRegistration number and expiry dateLocationLocation scaleQuantitative EffectsImpact on Business Performance

These are items the company does not state in this document. We do not leave them blank, nor fill them in from other sources or by inference.

The reasons the company gives

The company's own explanation, not something inferred from the numbers.

To report additional information on the Phase I trial presented at AACR 2026, following the interim results announced on 9 December 2025. In the Phase Ib trial, the dose and schedule will be reconsidered based on the results of the current trial.

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NANO MRNA Development Pipeline: Notice Regarding Presentation of Phase I Trial Results for the Novel Nucleic Acid Drug “TUG1 ASO” for Recurrent Glioblastoma at AACR 2026 | Nano Holdings,Inc. (4571) timely disclosure | Komori