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Other Disclosures4548SEIKAGAKU CORPORATIONPharmaceuticals

Notice of Publication of a Research Paper on Adhesion-Prevention Material SI-449 (Product Name: "CS Barrier")

A research paper on the domestic clinical trial of SI-449 (product name: CS Barrier), developed by the Company, was published in the medical journal JAMA Surgery. The paper covers research findings on efficacy and safety.

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Announced details

SI-449 (CS Barrier)
Applicable field (uses covered by this announcement)

Surgical field; open rectal resection (as stated in the paper title)

Relationship between the counterparty and the company
SEIKAGAKU CORPORATION4548
Relationship with the Company

The counterparty published the research paper on the domestic clinical trial of a product developed by the Company. Capital and personnel relationships: Not disclosed.

CounterpartyNational Cancer Center

Location: Chuo-ku, Tokyo; President: Mano Hiroyuki (間野 博行). A national research and development agency that published the research paper.

Registration number and expiry date

DOI:10.1001/jamasurg.2026.3416

In this announcement the company addresses none of Contract Value / Offering price / Impact on Business Performance.

Source (materials cited by the company)

JAMA Surgery

National Cancer Center Japan website

Announced details
ItemDetails
Names of Products / Services CoveredSI-449 (CS Barrier)
CounterpartyNational Cancer Center
Counterparty overviewLocation: Chuo-ku, Tokyo; President: Mano Hiroyuki (間野 博行). A national research and development agency that published the research paper.
Relationship with the CompanyThe counterparty published the research paper on the domestic clinical trial of a product developed by the Company. Capital and personnel relationships: Not disclosed.
Applicable areaSurgical field; open rectal resection (as stated in the paper title)
Registration number and expiry dateDOI:10.1001/jamasurg.2026.3416
SourceJAMA Surgery, National Cancer Center Japan website
Items this document does not state (11)
Contract ValueOffering priceContract DateLaunch dateAward/certification nameAwarding / certifying bodyLocationLocation scaleQuantitative EffectsUsage historyImpact on Business Performance

These are items the company does not state in this document. We do not leave them blank, nor fill them in from other sources or by inference.

The reasons the company gives

The company's own explanation, not something inferred from the numbers.

Because research findings on the efficacy and safety of SI-449 from the domestic clinical trial were published as a research paper.

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Notice of Publication of a Research Paper on Adhesion-Prevention Material SI-449 (Product Name: "CS Barrier") | SEIKAGAKU CORPORATION (4548) timely disclosure | Komori