Komori
Business alliance4519CHUGAI PHARMACEUTICAL CO.,LTD.Pharmaceuticals

Notice Regarding the Discontinuation of GYM329 (emugrobart) Development for Obesity, Return of the License, and Resumption of SMA Development

Chugai Pharmaceutical plans to discontinue Roche's development of emugrobart (GYM329) for obesity and have Roche return all license rights relating to the drug. For spinal muscular atrophy (SMA), Chugai will begin preparations to resume in-house development.

Worth reading
34Immaterial
Scored from 4 of 5 sections
Direction
Mixed performance
Direction inferred from the company’s description.
Scale
—
Displayed only when the document provides numerical figures.
Wording
Conditional
How definitive the wording is.

Agreements reached under this partnership

Discontinuation
4519CHUGAI PHARMACEUTICAL CO.,LTD.
Alliance partnerRoche
Details of the alliance
  1. 1

    Chugai Pharmaceutical plans to receive the return of all license rights relating to emugrobart from Roche

  2. 2

    Discontinue Roche's development of emugrobart

These are items that the documents state the two companies will work on. The lines above and below represent arrangements between the two companies.

Impact on Business Performance

This matter will have no impact on the consolidated earnings forecast for the fiscal year ending December 2026 announced on 29 January 2026.

Agreements reached under this partnership
ItemDetails
Name of alliance partnerRoche
Type of allianceDiscontinuation
Details of the allianceChugai Pharmaceutical plans to receive the return of all license rights relating to emugrobart from Roche, Discontinue Roche's development of emugrobart
Impact on Business PerformanceThis matter will have no impact on the consolidated earnings forecast for the fiscal year ending December 2026 announced on 29 January 2026.
Items this document does not state (19)
Alliance partner's business activitiesAlliance partner's locationAlliance partner's capitalAlliance partner's net salesAlliance partner's operating incomeNumber of shares acquiredAcquisition priceShareholding ratioOverview of the joint ventureOwnership ratioDispatch of directors and officersContract PeriodNumerical targets under the allianceShareholding PolicyDate of board resolutionContract DateAlliance start dateShare Acquisition Date and Payment DateChange in major shareholders

These are items the company does not state in this document. We do not leave them blank, nor fill them in from other sources or by inference.

The reasons the company gives

The company's own explanation, not something inferred from the numbers.

The decision to discontinue development for obesity was based on a comprehensive evaluation of the data, including the interim analysis results from the Phase II GYMINDA study, which indicated that achieving the prespecified clinically meaningful weight loss would be difficult. For SMA, Chugai identified an opportunity to resume development based on the subcutaneous route of administration, safety profile, pharmacodynamics, clinical signals and improvements to the Phase III trial design.

How to read this page

This is not the documentKomori reads the disclosure the company filed and writes this summary. Figures are as stated by the company and are not audited.
Weight is not a verdictIt measures how much this changes what the company had already told the market. It is not a view on the shares.
Corrections happenIf the company reissues this disclosure, the page is rebuilt from the corrected version and the revision number moves up.
Notice Regarding the Discontinuation of GYM329 (emugrobart) Development for Obesity, Return of the License, and Resumption of SMA Development | CHUGAI PHARMACEUTICAL CO.,LTD. (4519) timely disclosure | Komori