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Other Disclosures4506Sumitomo Pharma Co.,Ltd.Pharmaceuticals

Notice Regarding the Presentation of Updated Data on the Investigational Anticancer Drugs nuvisertib and enzomenib at the 2026 European Hematology Association (EHA) Congress

New clinical trial data and research findings on the investigational anticancer drugs nuvisertib and enzomenib were presented at the European Hematology Association Congress. The nuvisertib combination therapy demonstrated a certain level of efficacy and tolerability, while a gene mutation associated with post-treatment resistance was identified for enzomenib.

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Announced details

nuvisertibenzomenibnuvisertib and momelotinib combination therapy
Applicable field (uses covered by this announcement)
Relapsed or refractory myelofibrosisAcute leukemiaAcute myeloid leukemia
What the company reported numerically
Quantitative Effects

SVR25: 73% at week 12 and 100% at week 24 (n=5)

TSS50: 53% at week 12 and 60% at week 24 (n=5)

Anemia response: 50%

Triple response at week 24: 60%

DLT: 0 patients

E368K mutation: 53% of patients with relapsed disease

Usage history

As of 6 December 2025, 26 patients had been enrolled in the trial of the nuvisertib and momelotinib combination therapy. Of these, 15 patients were evaluable for efficacy and had completed at least 12 weeks of treatment.

Relationship between the counterparty and the company
Sumitomo Pharma Co.,Ltd.4506
Relationship with the Company

Sumitomo Pharma America, Inc., the US subsidiary of Sumitomo Pharma, presented research data at the congress.

CounterpartyEuropean Hematology Association (EHA)

European Hematology Association. Other information, including its location, representative, capital, and year of establishment, was not disclosed.

Location (as indicated in this announcement)

Stockholm, Sweden (venue of EHA 2026)

In this announcement the company addresses none of Contract Value / Offering price / Impact on Business Performance.

Source (materials cited by the company)

2026 Annual Congress of the European Hematology Association (EHA)

Announced details
ItemDetails
Names of Products / Services Coverednuvisertib, enzomenib, nuvisertib and momelotinib combination therapy
CounterpartyEuropean Hematology Association (EHA)
Counterparty overviewEuropean Hematology Association. Other information, including its location, representative, capital, and year of establishment, was not disclosed.
Relationship with the CompanySumitomo Pharma America, Inc., the US subsidiary of Sumitomo Pharma, presented research data at the congress.
Applicable areaRelapsed or refractory myelofibrosis, Acute leukemia, Acute myeloid leukemia
LocationStockholm, Sweden (venue of EHA 2026)
Quantitative EffectsSVR25: 73% at week 12 and 100% at week 24 (n=5), TSS50: 53% at week 12 and 60% at week 24 (n=5), Anemia response: 50%, Triple response at week 24: 60%, DLT: 0 patients, E368K mutation: 53% of patients with relapsed disease
Usage historyAs of 6 December 2025, 26 patients had been enrolled in the trial of the nuvisertib and momelotinib combination therapy. Of these, 15 patients were evaluable for efficacy and had completed at least 12 weeks of treatment.
Source2026 Annual Congress of the European Hematology Association (EHA)
Items this document does not state (9)
Contract ValueOffering priceContract DateLaunch dateAward/certification nameAwarding / certifying bodyRegistration number and expiry dateLocation scaleImpact on Business Performance

These are items the company does not state in this document. We do not leave them blank, nor fill them in from other sources or by inference.

The reasons the company gives

The company's own explanation, not something inferred from the numbers.

The presentations were made at the 2026 European Hematology Association Congress. For nuvisertib, the stated rationale was the need to inhibit multiple signaling pathways in myelofibrosis. For enzomenib, the findings clarified the mechanisms of acquired resistance after treatment and supported the investigation of sequential menin inhibitor therapy to improve treatment outcomes.

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Notice Regarding the Presentation of Updated Data on the Investigational Anticancer Drugs nuvisertib and enzomenib at the 2026 European Hematology Association (EHA) Congress | Sumitomo Pharma Co.,Ltd. (4506) timely disclosure | Komori