Announced details
TTR deposition was confirmed in the ileum, kidneys and sciatic nerves. The ileum and kidneys were analyzed at 26 and 52 weeks of age, and the sciatic nerves at 52 weeks of age.
Our company and its consolidated subsidiary Transgenic Inc. conducted joint research.
The respective research and medical departments of Kumamoto University, University of Toyama and Kobe University. No information is provided on their locations, representatives, capital or year of establishment.
A US patent was allowed in April 2026. The patent number and expiration date are Not disclosed
This matter will have no impact on consolidated results for the current fiscal year. The company will promptly disclose any matters that arise requiring disclosure.
The company does not address Contract Value / Offering price.
Academic journal Advances in Neurology and Neuroscience 9(3), 1–17 (2026), published on 19 August 2026
| Item | Details |
|---|---|
| Names of Products / Services Covered | TTR exon-humanized mice; exon-humanization technology |
| Counterparty | Center for Animal Resources and Development, Kumamoto University, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Kobe University Hospital |
| Counterparty overview | The respective research and medical departments of Kumamoto University, University of Toyama and Kobe University. No information is provided on their locations, representatives, capital or year of establishment. |
| Relationship with the Company | Our company and its consolidated subsidiary Transgenic Inc. conducted joint research. |
| Applicable area | Elucidation of the pathogenesis of hereditary ATTR amyloidosis, Drug Discovery Research, Preclinical research on nucleic acid therapeutics, gene therapy and TTR-stabilizing therapeutic candidates |
| Registration number and expiry date | A US patent was allowed in April 2026. The patent number and expiration date are Not disclosed |
| Quantitative Effects | TTR deposition was confirmed in the ileum, kidneys and sciatic nerves. The ileum and kidneys were analyzed at 26 and 52 weeks of age, and the sciatic nerves at 52 weeks of age. |
| Impact on Business Performance | This matter will have no impact on consolidated results for the current fiscal year. The company will promptly disclose any matters that arise requiring disclosure. |
| Source | Academic journal Advances in Neurology and Neuroscience 9(3), 1–17 (2026), published on 19 August 2026 |
Items this document does not state (9)
These are items the company does not state in this document. We do not leave them blank, nor fill them in from other sources or by inference.
The reasons the company gives
The company's own explanation, not something inferred from the numbers.The model enables appropriate evaluation of human TTR expression and tissue deposition, as well as analysis of the deposition process before mature amyloid fibrils form and differences by genotype and age in weeks.